Acyclic Nucleotides Related to Clitocine: Synthesis and Anti-HIV Activity |
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| Authors: | P. Franchetti L. Cappellacci G. Abu Sheikha M. Grifantini A. G. Loi A. De Montis |
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| Affiliation: | 1. Dipartimento di Scienze Chimiche , Università di Camerino , 62032, Camerino;2. Dipartimento di Biologia Sperimentale , Universitág di Cagliari , 09124, Cagliari, Italy |
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| Abstract: | Abstract The syntheses and antiviral activity of analogues of the anti-HIV agents PMEA, PMEDAP, (R)-PMPA, (R)-PMPDAP are described. In these analogues the adenine moiety is replaced by 4,6-diamino-5-nitro-pyrimidine (the aglycon of clitocine) or 2,4,6-triamino-5-nitro-pyrimidine. The synthesis of similar acyclic phosphonates related to PMEG and (R)-2′-methyl-PMEG is also reported. Some compounds proved to be active as anti-HIV agents. |
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