Guanosine Derivatives as Immunostimulants. Discovery of Loxoribine |
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| Authors: | Robert Chen Michael G. Goodman Dennis Argentieri Stanley C. Bell Levelle E. Burr Jon Come |
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| Affiliation: | 1. The R. W. Johnson Pharmaceutical Research Institute (PRI) and The Scripps Research Institute (TSRI);2. PRI, Medicinal Chemistry Department , Raritan, New Jersey, 08869, USA;3. TSRI, Department of Immunology , La Jolla, California, 92037, USA;4. PRI, Immunopharmacology , Raritan, New Jersey, 08869, USA;5. PRI, Medicinal Chemistry Department , Spring House, Pennsylvania, 19477, USA |
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| Abstract: | Abstract 7-Allyl-8-oxoguanosine (loxoribine, 5) was selected from a series of guanosine derivatives for further evaluation as an immunostimulant. Numerous related analogs were also synthesized and evaluated: 2′,3′-ketals of 5 are particularly interesting because they are active, apparently without being cleaved to the free nucleoside. |
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