Synthesis of L-Sangivamycin and Toyocamycin Analogues and Their Inhibitory Activities of SER/THR Protein Kinases |
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| Authors: | Moon Woo Chun Dae Hong Shin Sun Yong Song Yong Hee Lee Chul Hoon Lee Lak Shin Jeong |
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| Affiliation: | 1. College of Pharmacy, Seoul National University , Seoul, 151-742;2. Research and Development Center , Cheil Foods &3. Chemicals Inc. , Ichun, 467-810, Korea;4. Laboratory of Medicinal Chemistry , College of Pharmacy, Ewha Womans University , Seoul, 120-750, Korea |
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| Abstract: | Abstract Novel l-sangivamycin and toyocamycin analogues were synthesized and evaluated for Cdc2 protein kinase activity. Among the compounds tested, l-xylose derivative and l-arabinose derivative exhibited potent inhibitory activity against Cdc2 protein kinase with IC50 values of 3.7 and 1.6 μM, respectively. |
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