Synthesis of 9-(2-Hydroxyethoxymethyl)guanine (Acyclovir) from Guanosine |
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| Authors: | Hiroshi Shiragami Yoshihito Koguchi Yasuhiro Tanaka Satoshi Takamatsu Yumiko Uchida Takashi Ineyama |
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| Affiliation: | Central Research Laboratories, Ajinomoto Co., Inc , 1-1 Suzuki-cho, Kawasaki-ku, Kawasaki, 210, Japan |
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| Abstract: | Abstract A convenient synthesis of 9-(2-hydroxyethoxymethyl)guanine (acyclovir) from guanosine by chemical transpurination was developed. The isomerization of the 7-isomer to the desired 9-isomer and the purification of the 9-isomer was achieved simply by concentration, heating and further crystallization. |
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