Anti-HIV Pronucleotides: SATE Versus Phenyl as a Protecting Group of AZT Phosphoramidate Derivatives |
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| Authors: | T. Beltran D. Egron I. Lefebvre C. Périgaud A. Pompon G. Gosselin |
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| Affiliation: | Laboratoire de Chimie Bioorganique, UMR CNRS-USTL 5625 , Université Montpellier II , Case courrier 008, Place E. Bataillon, 34095, Montpellier Cedex 5, France |
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| Abstract: | ![]()
Abstract We comparatively studied the decomposition pathways in CEM cell extract of several PHENYL phosphoramidate diesters of AZT. A correlation between anti-HIV activities in TK? cell lines and pharmacokinetic data has been observed. This study would help to design corresponding SATE phosphoramidate diesters which revealed potent anti-HIV properties. |
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