Phosphate-Modified Nucleotides: Conversions in Human Serum |
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| Authors: | Marina K Kukhanova Elena V Kuznetsova Andrey A Arzumanov Alexander A Krayevsky |
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| Institution: | Engelhardt Institute of Molecular Biology, Russian Academy of Sciences , Vavilov str., 32, 117984, Moscow, Russia |
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| Abstract: | Abstract Mechanisms and rates of hydrolytic dephosphorylation of 5′-hydrogenphosphonates, 5′-phosphorofluoridates, and 5′-phosphates of natural and 3′-substituted thymidines in human serum were studied. The stability of 5′-phosphonates of 2′-deoxy- and 2′,3′-dideoxyadenosines in calf and human sera was found. |
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