Synthesis of 2-Chloro-6-aryloxy- and 2-Chloro-6-alkoxyarylpurines and Their Properties in the Purine Nucleoside Phosphorylase (PNP) System |
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| Authors: | A. Bzowska L. Magnowska B. Wielgus-kutrowska Z. Kazimierczuk |
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| Affiliation: | Department of Biophysics , Institute of Experimental Physics, University of Warsaw , Z˙wirki i Wigury 93, 02 089, Warsaw, Poland |
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| Abstract: | ![]()
Abstract A series of 2-chloro-6-aryloxy- and 2-chloro-6-alkoxyarylpurines was synthesized and their kinetic properties in the purine nucleoside phosphorylase (PNP) system were determined. All compounds showed inhibitory activity (IC50 in the range 0.5-76 μM) vs. hexameric (“high-molecular weight”) PNP from E. coli. By contrast, no inhibition vs. trimeric Cellulomonas PNP was detected. |
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