Downregulation of muscle protein degradation in sepsis by eicosapentaenoic acid (EPA) |
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Authors: | Khal Jwan Tisdale Michael J |
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Institution: | Nutritional Biomedicine, School of Life and Health Sciences, Aston University, Aston Triangle, Birmingham B4 7ET, UK |
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Abstract: | Eicosapentaenoic acid (EPA) has been shown to attenuate muscle atrophy in cancer, starvation and hyperthermia by downregulating the increased expression of the ubiquitin-proteasome proteolytic pathway leading to a reduction in protein degradation. In the current study EPA (0.5 g/kg) administered to septic mice completely attenuated the increased protein degradation in skeletal muscle by preventing the increase in both gene expression and protein concentration of the α- and β-subunits of the 20S proteasome, as well as functional activity of the proteasome, as measured by the ‘chymotrypsin-like’ enzyme activity. These results suggest that muscle protein catabolism in sepsis is mediated by the same intracellular signalling pathways as found in other catabolic conditions. |
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Keywords: | Sepsis Muscle atrophy EPA Ubiquitin-proteasome proteolysis |
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