High-Resolution Proton Magnetic Resonance Analysis of Human Cerebrospinal Fluid |
| |
Authors: | O A C Petroff R K Yu T Ogino |
| |
Institution: | Departments of Neurology and Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut, U.S.A. |
| |
Abstract: | High-resolution proton magnetic resonance spectroscopy was used to analyze human cerebrospinal fluid obtained from patients with several neurological problems. The major metabolites measured included glucose, lactate, glutamine, citrate, inositol, acetate, creatine, creatinine, beta-hydroxybutyrate, alanine, and pyruvate. A drug vehicle, propylene glycol, was also measured. Alterations in the cerebrospinal fluid of these metabolites provided information concerning metabolism of the brain. Magnetic resonance spectroscopy offered a simple and rapid means of assessing these and other exogenous and endogenous compounds in diseases affecting the nervous system. |
| |
Keywords: | Cerebrospinal fluid Human Nuclear magnetic resonance spectroscopy Major metabolites |
本文献已被 PubMed 等数据库收录! |
|