Antimicrobial metabolites produced by an intertidal Acremonium furcatum |
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| Authors: | Gallardo Gabriela L Butler Matías Gallo Mariana L Rodríguez M Alejandra Eberlin Marcos N Cabrera Gabriela M |
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| Institution: | Departamento de Química Orgánica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Pab. II, 1428 Buenos Aires, Argentina. |
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| Abstract: | In a screening for antimicrobial metabolites, amides of D-allo- and L-isoleucine derivatives were isolated from the culture of a marine strain of Acremonium furcatum. Structural elucidation of these compounds was performed by analysis of spectroscopic data and confirmed by synthesis. All of the compounds, natural and synthetic intermediates, were bioassayed against bacteria and phytopathogenic fungi, with many showing remarkable antifungal activities. |
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| Keywords: | Acremonium furcatum Marine fungi Isoleucinol Isoleucinaldehyde Isoleucine derivatives Antifungal activity Fusarium virguliforme Colletotrichum truncatum |
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