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Identification of genes differentially expressed in dorsal and ventral chick midbrain during early Development |
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| Authors: | A Chittka JN Volff A Wizenmann |
| Institution: | 1. Junior Research Group, Biozentrum, Am Hubland, Würzburg, 97074, Germany 3. MRC Laboratory for Molecular Cell Biology, UCL, Gower Street, London, WC1E 6BT, UK 2. Institut de Génomique Fonctionnelle de Lyon; Université de Lyon; Institut Fédératif Biosciences Gerland Lyon Sud; Université Lyon 1, CNRS, INRA, Ecole Normale Supérieure de Lyon, Lyon, France 4. Institute for Anatomy, Experimental Embryology, ?sterbergstrasse, Tübingen, Germany |
| Abstract: | BackgroundDuring the development of the central nervous system (CNS), patterning processes along the dorsoventral (DV) axis of the neural tube generate different neuronal subtypes. As development progresses these neurons are arranged into functional units with varying cytoarchitecture, such as laminae or nuclei for efficient relaying of information. Early in development ventral and dorsal regions are similar in size and structure. Different proliferation rates and cell migration patterns are likely to result in the formation of laminae or nuclei, eventually. However, the underlying molecular mechanisms that establish these different structural arrangements are not well understood. |
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