Institute for Biological Resources and Functions, National Institute of Advanced Industrial Science and Technology, AIST, Central 6, 1-1-1 Higashi, Tsukuba 305-8566, Japan.
Abstract:
DNA-loaded microtubules (MTs) moving on a kinesin motor protein-coated substrate can selectively hybridize with a target fully matched DNA over single-base mismatched DNA and transport it. This technique is capable of collecting target biomolecules toward one point site to design new methodology of DNA analysis.