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Selective detection and transport of fully matched DNA by DNA-loaded microtubule and kinesin motor protein
Authors:Taira Shu  Du Yong-Zhong  Hiratsuka Yuichi  Konishi Kaoru  Kubo Tai  Uyeda Taro Q P  Yumoto Noboru  Kodaka Masato
Affiliation:Institute for Biological Resources and Functions, National Institute of Advanced Industrial Science and Technology, AIST, Central 6, 1-1-1 Higashi, Tsukuba 305-8566, Japan.
Abstract:DNA-loaded microtubules (MTs) moving on a kinesin motor protein-coated substrate can selectively hybridize with a target fully matched DNA over single-base mismatched DNA and transport it. This technique is capable of collecting target biomolecules toward one point site to design new methodology of DNA analysis.
Keywords:DNA‐loaded microtubules  motor protein  SNP
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