Survival of orally administered isolated intestinalLactobacillus acidophilus in different parts of gastrointestinal tract of mice |
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| Authors: | Pramatha R Bhattacharya M K Majumdar |
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| Institution: | (1) Central Drugs Laboratory, 3, Kyd Street, 700 016 Calcutta;(2) Present address: Connecticut Health Centre, University of Connecticut, Farmington, USA |
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| Abstract: | A strain ofLactobacillus acidophilus (Strain HF) was isolated from human faeces. A chloramphenicol resistant strain (HFCm) and a strain (HFCmSm) restant to both
chloramphenicol and streptomycin were developed from the isolated strain (HF). All the three strains showed similarin vitro susceptibility against host defence factors like gastric acid, bile salts and volatile as well as non-volatile fatty acids.In vivo tests were done by feeding these strains to mice. When the resistant strains were orally administered along with the antibiotic(s)
they were stable up to 72 h |
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| Keywords: | Lactobacillus acidophilus intestinal lactobacilli antibiotic-resistant lactobacilli streptomycin chloramphenicol |
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