Glucose-6-phosphate dehydrogenase deficiency: a novel role for thyroxine in peroxide-induced hemolysis |
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Authors: | R Walls P Hochstein |
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Institution: | Department of Pharmacology, University of Southern California School of Medicine, Los Angeles, California 90033, USA |
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Abstract: | G-6-PD deficient erythrocytes undergo hemolysis during exposure to hydrogen peroxide and thyroxine. Normal erythrocytes do not show this effect unless incubated in the absence of glucose. The inability of G-6-PD deficient cells to detoxify hydrogen peroxide apparently exposes them to the cytotoxic actions of thyroxine. It is suggested that the hemolysis and anemia associated with this genetic disorder is a consequence of the actions of both peroxide and thyroxine on erythrocyte membranes. |
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