Create and preserve: Proteostasis in development and aging is governed by Cdc48/p97/VCP |
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Authors: | André Franz,Leena Ackermann,Thorsten Hoppe |
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Affiliation: | Institute for Genetics and Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Zülpicher Straße 47a, 50674 Cologne, Germany |
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Abstract: | The AAA-ATPase Cdc48 (also called p97 or VCP) acts as a key regulator in proteolytic pathways, coordinating recruitment and targeting of substrate proteins to the 26S proteasome or lysosomal degradation. However, in contrast to the well-known function in ubiquitin-dependent cellular processes, the physiological relevance of Cdc48 in organismic development and maintenance of protein homeostasis is less understood. Therefore, studies on multicellular model organisms help to decipher how Cdc48-dependent proteolysis is regulated in time and space to meet developmental requirements. Given the importance of developmental regulation and tissue maintenance, defects in Cdc48 activity have been linked to several human pathologies including protein aggregation diseases. Thus, addressing the underlying disease mechanisms not only contributes to our understanding on the organism-wide function of Cdc48 but also facilitates the design of specific medical therapies. In this review, we will portray the role of Cdc48 in the context of multicellular organisms, pointing out its importance for developmental processes, tissue surveillance, and disease prevention. This article is part of a Special Issue entitled: Ubiquitin–Proteasome System. Guest Editors: Thomas Sommer and Dieter H. Wolf. |
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Keywords: | AAA, ATPase associated with diverse cellular activities AD, Alzheimer's disease ALS, amyotrophic lateral sclerosis AMPK, adenosine monophosphate activated kinase Cdc48/CDC-48, cell division cycle protein 48 DUB, de-ubiquitylating enzyme ERAD, endoplasmic reticulum-associated degradation HD, Huntington's disease IBMPFD, inclusion body myopathy with Paget's disease of bone and frontotemporal dementia MAD, mitochondria-associated degradation MJD, Machado&ndash Joseph disease OMM, outer mitochondrial membrane polyQ, extended poly-glutamine stretch STUbL, SUMO-targeted ubiquitin ligase TLS pol, translesional DNA polymerases TOR, target of rapamycin UBX, ubiquitin regulatory x UPS, ubiquitin&ndash proteasome system VCP, valosin-containing protein |
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