Iron starvation triggers the stringent response and induces amino acid biosynthesis for bacillibactin production in Bacillus subtilis |
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| Authors: | Miethke Marcus Westers Helga Blom Evert-Jan Kuipers Oscar P Marahiel Mohamed A |
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| Affiliation: | Fachbereich Chemie/Biochemie der Philipps-Universit?t Marburg, Marburg, Germany. |
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| Abstract: | Iron deprivation in bacteria causes the derepression of genes controlled by the ferric uptake regulator (Fur). The present microarray analysis of iron-starved Bacillus subtilis cells grown in minimal medium unveils additional physiological effects on a large number of genes linked to stringent-response regulation and to genes involved in amino acid biosynthesis associated with pathways essential for bacillibactin production. |
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