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NMR assignment of human granulocyte-macrophage colony-stimulating factor |
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| Authors: | Simon Sauvé Geneviève Gingras Yves Aubin |
| Affiliation: | (1) Centre for Biologics Research, Biologics and Genetic Therapies Directorate, Health Canada, 251 Sir Frederick Banting Driveway, A/L 2201E, Tunney’s Pasture, Ottawa, ON, Canada, K1A 0K9;(2) Department of Chemistry, Carleton University, Ottawa, ON, Canada, K1S 5B6;(3) Department of Biochemistry, Molecular Biology and Immunology, University of Ottawa, Ottawa, ON, Canada, K1H 8M5;(4) Department of Biochemistry, Université de Montréal, Montreal, QC, Canada, H3T 1J4 |
| Abstract: | Human granulocyte-macrophage colony-stimulating factor (hGM-CSF), also known as sargramostim or molgramostin, is a cytokine that functions as a hematopoietic cell growth factor. Here we report a near complete assignment for the backbone and side chain resonances for the mature polypeptide. |
| Keywords: | Granulocyte-macrophage colony-stimulating factor Recombinant protein therapeutics Protein characterization |
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