Proteolytic system in lungs upon inhalation exposure to low doses of lead salts |
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| Authors: | Likholat E A Anan'eva T V Antoniuk S V Lutova N B |
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| Affiliation: | Ukrainian State Research Institute of Medical and Social Problems of Physical Disability, Dnipropetrovsk. |
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| Abstract: | Changes in proteinase--antiproteinase activities in lungs as a result of short-term (for 1 week) inhalation of rats with 0.01% (CH3COO)2 Pb have wholly compensative patterns, but it have been found increased cathepsine B activity as a negative prognostic factor. Chronic (for 2 month) toxicant inhalation caused considerable activation of both trypsine and cathepsine B under decreasing alpha 1-antitrypsine and alpha 2-macroglobuline activities. Cathepsine L activity was not affected. Disorders in the proteolysis system were evaluated as desadaptation situation in lung tissue under chronic toxic influence. |
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