Mechanism of decreased insulinogenesis in manganese-deficient rats. Decreased insulin mRNA levels |
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| Authors: | D L Baly I Lee R Doshi |
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| Affiliation: | Department of Nutrition, Rutgers University, New Brunswick, NJ 08903. |
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| Abstract: | Manganese-deficient rats exhibited seven-fold lower preproinsulin mRNA levels compared to control, as detected by dot blot hybridization of both total and poly(A)+ RNA using a preproinsulin cDNA probe. No differences in the size of the insulin mRNA were observed. Thus, decreased mRNA levels may be a major contributing factor to the decreased insulinogenesis observed in manganese-deficient rats. |
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