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Mechanism of decreased insulinogenesis in manganese-deficient rats. Decreased insulin mRNA levels
Authors:D L Baly  I Lee  R Doshi
Affiliation:Department of Nutrition, Rutgers University, New Brunswick, NJ 08903.
Abstract:Manganese-deficient rats exhibited seven-fold lower preproinsulin mRNA levels compared to control, as detected by dot blot hybridization of both total and poly(A)+ RNA using a preproinsulin cDNA probe. No differences in the size of the insulin mRNA were observed. Thus, decreased mRNA levels may be a major contributing factor to the decreased insulinogenesis observed in manganese-deficient rats.
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