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Hydroperoxy-cycloartane triterpenoids from the leaves of Markhamia lutea, a plant ingested by wild chimpanzees |
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| Authors: | Damien Lacroix Soizic Prado Alexandre Deville Sabrina Krief Vincent Dumontet John Kasenene Elisabeth Mouray Christian Bories Bernard Bodo |
| Affiliation: | a Molécules de Communication et Adaptation des Micro-organismes, Unité Associée au CNRS, Muséum National d’Histoire Naturelle, 57 Rue Cuvier, 75005 Paris, France b Eco-anthropologie et Ethnobiologie, MNHN-CNRS, 43 Rue Buffon, 75005 Paris, France c Institut de Chimie des Substances Naturelles, CNRS, Avenue de la Terrasse 91198 Gif-sur-Yvette, France d Department of Botany, Makerere University, P.O. Box 7062, Kampala, Uganda e Chimiothérapie Antiparasitaire, CNRS, Faculté de Pharmacie, Université Paris Sud, 92200 Châtenay-Malabry, France |
| Abstract: | In the framework of the phytochemical investigation of plant species eaten by wild chimpanzees in their natural environment in Uganda, leaf samples of Markhamia lutea were selected and collected. The crude ethyl acetate extract of M. lutea leaves exhibited significant in vitro anti-parasitic activity and low cytotoxicity against MRC5 and KB cells. Fractionation of this extract led to six cycloartane triterpenoids, musambins A–C and their 3-O-xyloside derivatives musambiosides A–C. The structures were elucidated on the basis of spectral studies including mass spectroscopy and extensive 2D NMR. Most of the compounds exhibited mild anti-leishmanial and anti-trypanosomal activities. |
| Keywords: | Cycloartane Triterpenoid hydroperoxides Markhamia lutea Bignoniaceae Anti-parasitic activities Zoopharmacognosy Chimpanzees |
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