Experimental manipulation of immune-mediated disease and its fitness costs for rodent malaria parasites |
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Authors: | Gráinne H Long Brian HK Chan Judith E Allen Andrew F Read Andrea L Graham |
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Institution: | (1) Institutes of Evolution, Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, King's Buildings, West Mains Road, Edinburgh, EH9 3JT, UK;(2) Center for Infectious Disease Dynamics, Department of Biology, Mueller Laboratory, The Pennsylvania State University, University Park, Pennsylvania 16802, USA |
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Abstract: | Background Explaining parasite virulence (harm to the host) represents a major challenge for evolutionary and biomedical scientists alike.
Most theoretical models of virulence evolution assume that virulence arises as a direct consequence of host exploitation,
the process whereby parasites convert host resources into transmission opportunities. However, infection-induced disease can
be immune-mediated (immunopathology). Little is known about how immunopathology affects parasite fitness, or how it will affect
the evolution of parasite virulence. Here we studied the effects of immunopathology on infection-induced host mortality rate
and lifetime transmission potential – key components of parasite fitness – using the rodent malaria model, Plasmodium chabaudi chabaudi. |
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