Phylogenetic analysis of the SAP30 family of transcriptional regulators reveals functional divergence in the domain that binds the nuclear matrix |
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| Authors: | Keijo M Viiri Taisto YK Heinonen Markku Mäki Olli Lohi |
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| Affiliation: | (1) Paediatric Research Centre, University of Tampere Medical School and Tampere University Hospital, 33520 Tampere, Finland |
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| Abstract: | Background Deacetylation of histones plays a fundamental role in gene silencing, and this is mediated by a corepressor complex containing
Sin3 as an essential scaffold protein. In this report we examine the evolution of two proteins in this complex, the Sin3-associated
proteins SAP30L and SAP30, by using an archive of protein sequences from 62 species. |
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