D-Amino acid production from racemic amino acids by a microbial asymmetric degradation |
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| Authors: | E. Takahashi M. Furui T. Shibatani |
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| Affiliation: | (1) Pharmaceutical Development Research Laboratory, Tanabe Seiyaku Co. Ltd., 16–89, Kashima-3-chome, Yodogawa-ku Osaka, 532, Japan;(2) Technical Department, Sun Chemical Co. Ltd., 29–3, Shinmachi, Yashio Saitama, 340, Japan |
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| Abstract: | To obtain D-amino acid from a mixture of racemic amino acids, Proteus vulgaris, having the ability of selective degradation of L-isomer in various DL-amino acids mixtures, was used as a biocatalyst. D-Isomer crystals of valine, leucine, isoleucine, histidine and ornithine were isolated at a good yield (25~41%) from the reaction mixture after 24~72 hours. |
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