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A bursal pentapeptide (BPP-I), a novel bursal-derived peptide, exhibits antiproliferation of tumor cell and immunomodulator activity |
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| Authors: | Xiu L. Feng Qing T. Liu Rui B. Cao Bin Zhou Fang Q. Wang Wen L. Deng Ya F. Qiu Yu Zhang Hassan Ishag Zhi Y. Ma Qi S. Zheng Pu Y. Chen |
| Affiliation: | 1. Division of Key Lab of Animal Disease Diagnosis and Immunology of China’s Department of Agriculture, College of Veterinary Medicine, Nanjing Agriculture University, Nanjing, 210095, People’s Republic of China 2. Nanjing Tianbang Bio-Industry Co. Ltd, Nanjing, People’s Republic of China 3. Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Science, Shanghai, 200241, People’s Republic of China 4. Division of National Veterinary Biological Medicine Engineering Research Center, Nanjing, People’s Republic of China |
| Abstract: | The bursa of Fabricius (BF) is the central humoral immune organ unique to birds. Here, we isolated a novel bursal pentapeptide I (BPP-I), LGPGP, from BF. BPP-I could play inhibition effect on MCF-7 but not on CEF or Vero cell proliferation in vitro, and enhance antitumor factor p53 protein expression. Also, BPP-I stimulated antibody production in a dose-dependent manner in hybridoma cell. Furthermore, BPP-I could induce various immune responses in mice immunization experiments, including increase antibody production and cytokines IL-4 and IFN-γ level, and induce T-cell immunophenotyping. These results suggest that BPP-I is a potential immunomodulator of antitumor and immunity. The study could provide some novel insights on the probable candidate reagent for the antitumor and immune improvement. |
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