| β-adrenergic modulation of in vivo long-term potentiation in area CA1 and its role in spatial learning in rats |
| |
| 引用本文： | 季今朝,张雪寒,李葆明.β-adrenergic modulation of in vivo long-term potentiation in area CA1 and its role in spatial learning in rats[J].中国科学：生命科学英文版,2003,46(6). |
| |
| 作者姓名： | 季今朝 张雪寒 李葆明 |
| |
| 作者单位： | Laboratory of Higher Brain Functions，Institute of Neurobiology，Fudan University，Shanghai 200433，China，Shanghai Institute of Physiology，Shanghai Institutes of Biological Sciences，Chinese Academy of Sciences，Shanghai 200031，China，Laboratory of Higher Brain Functions，Institute of Neurobiology，Fudan University，Shanghai 200433，China，Laboratory of Higher Brain Functions，Institute of Neurobiology，Fudan University，Shanghai 200433，China |
| |
| 基金项目： | 国家自然科学基金，上海市科技发展基金，科技部资助项目 |
| |
| 摘 要： | The hippocampus plays a key role in declarative learning and memory 1]. Hippocampal long-term potentiation (LTP) is a type of synaptic plasticity that has been widely studied as a syn-aptic mechanism underlying learning and memory27]. It has been reported that in vitro LTP in area CA1 is subjected to b-adrenergic modulation. For example, the theta-pulse stimulation (510 Hz), a neutral frequency not modifying synaptic strength, can elicit a robust LTP in area CA1 in slice when the b-adr…
|
| 关 键 词： | β-adrenoceptor |
β-adrenergic modulation of in vivo long-term potentiation in area CA1 and its role in spatial learning in rats |
| |
| JI Jinzhao ,ZHANG Xuehan & LI Baoming . Laboratory of Higher Brain Functions.β-adrenergic modulation of in vivo long-term potentiation in area CA1 and its role in spatial learning in rats[J].Science China Life sciences,2003,46(6). |
| |
| Authors: | JI Jinzhao ZHANG Xuehan & LI Baoming Laboratory of Higher Brain Functions |
| |
| Institution: | JI Jinzhao 1,2*,ZHANG Xuehan 1* & LI Baoming 1 1. Laboratory of Higher Brain Functions,Institute of Neurobiology,Fudan University,Shanghai 200433,China, 2. Shanghai Institute of Physiology,Shanghai Institutes of Biological Sciences,Chinese Academy of Sciences,Shanghai 200031,China |
| |
| Abstract: | Activation of b-adrenoceptors in area CA1 of the hippocampus facilitates in vitro long-term potentiation (LTP) in this region. However, it is unclear if in vivo LTP in area CA1 and hippocampus-dependent learning are subjected to b-adrenergic regulation. To address this ques-tion, we investigated the effects of the b-adrenergic agonist L-isoproterenol or antagonist DL-propranolol on in vivo LTP of area CA1 and the spatial learning in Morris water maze. In the presence of L-isoproterenol (through local infusion into area CA1), the theta-pulse stimulation with the parameter of 10 Hz, 150 pulses/train, 1 train, a frequency weakly modifying synaptic strength, induced a robust LTP, and this effect was blocked when DL-propranolol was co-administered. By contrast, the theta-pulse stimulation with the parameter of 5 Hz, 150 pulses/train, 3 trains, a fre-quency strongly modifying synaptic strength, induced a significantly smaller LTP when DL-propranolol was administered into area CA1. Accordingly, DL-propranolol impaired the spatial learning in the water maze when infused into area CA1 20 min pretraining. Compared with control rats, the DL-propranolol-treated rats showed significantly slower learning in the water maze and subsequently exhibited poor memory retention at 24-h test. These results suggest that b-adrenoceptors in area CA1 are involved in regulating in vivo synaptic plasticity of this area and are important for spatial learning. |
| |
| Keywords: | b-adrenoceptor long-term potentiation CA1 hippocampus spatial learning rat |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
