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Structural Survey of Broadly Neutralizing Antibodies Targeting the HIV-1 Env Trimer Delineates Epitope Categories and Characteristics of Recognition |
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| Authors: | Gwo-Yu Chuang Jing Zhou Priyamvada Acharya Reda Rawi Chen-Hsiang Shen Zizhang Sheng Baoshan Zhang Tongqing Zhou Robert T Bailer Venkata P Dandey Nicole A Doria-Rose Mark K Louder Krisha McKee John R Mascola Lawrence Shapiro Peter D Kwong |
| Institution: | 1. Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA;2. National Resource for Automated Molecular Microscopy, Simons Electron Microscopy Center, New York Structural Biology Center, New York, NY 10027, USA;3. Department of Biochemistry and Molecular Biophysics & Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10032, USA |
| Abstract: |  |
| Keywords: | antibody recognition B cell ontogeny broadly neutralizing antibody cryo-electron microscopy envelope glycoprotein trimer glycan shielding sequence variation vaccine design X-ray crystallography |
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