Isoflavones inhibit 3-hydroxy-3-methylglutaryl coenzyme A reductase in vitro |
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| Authors: | Sung Jang Hoon Lee Sung-Joon Park Kwan Hwa Moon Tae Wha |
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| Affiliation: | Department of Food Science and Technology, School of Agricultural Biotechnology, and Center for Agricultural Biomaterials, Seoul National University, Korea. |
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| Abstract: | Isoflavones identified as inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase in soybean paste were assayed using the catalytic portion of Syrian hamster HMG-CoA reductase, and the kinetic values were measured using HMG-CoA and NADPH. The inhibition of HMG-CoA reductase by these inhibitors was competitive with HMG-CoA and noncompetitive with NADPH. Ki values for genistein, daidzein, and glycitein were 27.7, 49.5, and 94.7 microM, respectively. |
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