The inhibitory effect of naringenin on atopic dermatitis induced by DNFB in NC/Nga mice |
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Authors: | Tae-Ho Kim Gun-Dong KimHyun-Jong Ahn Jeong-Je ChoYong Seek Park Cheung-Seog Park |
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Institution: | Department of Microbiology, School of Medicine, Kyung Hee University, Seoul, Republic of Korea |
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Abstract: | AimsAtopic dermatitis (AD) is a chronic and relapsing inflammatory dermatitis characterized by pruritic and eczematous skin lesions. Here, we investigated the therapeutic effect of the fruit flavonoid naringenin on DNFB induced atopic dermatitis mice model.Main methodsAD-like skin lesion was induced by repetitive skin contact with DNFB in NC/Nga mice and the effects of the fruit flavonoid naringenin were evaluated on the basis of histopathological findings of skin, ear swelling and cytokine production of CD4+T cells.Key findingsIntraperitoneal injection of naringenin for one week after DNFB challenge significantly lowered ear swelling and improved back skin lesions. In addition, naringenin significantly suppressed production of interferon-gamma (IFN-γ) by activated CD4+ T cells and serum IgE level. Furthermore, naringenin reduced DNFB-induced infiltration of eosinophils, mast cells, CD4+ T cells, and CD8+ T cells in skin lesions.SignificanceNaringenin may suppress the development of AD-like skin lesions in DNFB-treated NC/Nga mice by reducing IFN-γ production of activated CD4+ T cells, serum IgE levels and infiltration of immune cells to skin lesion. |
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Keywords: | Atopic dermatitis Naringenin 2 4-dinitrofluorobenzene Skin barrier NC Nga mice |
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