产前B族链球菌筛查对妊娠结局及新生儿的影响

目的研究妊娠期B族链球菌(GBS)感染对妊娠结局和新生儿的影响,探讨GBS筛查的临床意义。方法选取2016年1月至2017年6月在我院进行GBS筛查的800例孕妇为受试对象,实时荧光定量PCR技术检测GBS携带情况,根据GBS筛查结果及是否愿意接受干预治疗分为治疗组、非治疗组和GBS阴性组,对比三组妊娠结局、新生儿情况。结果 800例受试对象中,GBS阳性136例(17.0%);治疗组胎膜早破、早产、宫内感染、胎儿窘迫及新生儿肺炎、窒息、败血症、病理性黄疸发生率与GBS阴性组相比,差异均无统计学意义(Ps0.05);而与非治疗组相比,除新生儿脑膜炎差异无统计学意义(P0.05)外,其他指标差异均有统计学意义(Ps0.05)。结论妊娠期进行GBS感染的筛查具有重要意义,及时采取干预措施可有效减少不良妊娠结局及新生儿感染的发生率。

Effect of Group B Streptococcus screening on pregnancy outcome and neonatals

Abstract: Objective To study the effect of Group B Streptococcus (GBS) infection during pregnancy on pregnancy outcome and neonatals, and explore the clinical significance of GBS screening. Methods 800 pregnant women accepting GBS screening in our hospital from January 2016 to June 2017 were selected as the subjects. PCR technique was used to detect the GBS. According to the results of GBS screening and whether willing to receive intervention treatment, the women were divided into three groups: treatment group, non-treatment group and GBS negative group. The pregnancy outcomes and conditions of neonates were compared among the three groups. Results 136 cases (17%) were positive for GBS. The rates of premature rupture of membranes, premature delivery, intrauterine infection, fetal distress & neonatal pneumonia, asphyxia, septicemia and pathological jaundice in the treatment group were not statistically different from those in GBS negative group (Ps>0.05). However, there were significant differences between treatmet group and non-treatment group in all the indexes expect neonatal meningitis. Conclusion It is of great significance to conduct screening of GBS during pregnancy. Timely intervention can effectively reduce the incidence rates of bad pregnancy outcome and neonatal infection.