| B群脑膜炎球菌多组分疫苗研究进展 |
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| 引用本文： | 李开铭[综述],彭杰[综述],钟美珍[综述],胡四海[审校].B群脑膜炎球菌多组分疫苗研究进展[J].微生物学免疫学进展,2014(2):46-49. |
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| 作者姓名： | 李开铭[综述] 彭杰[综述] 钟美珍[综述] 胡四海[审校] |
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| 作者单位： | [1]南华大学病原生物学研究所,湖南衡阳421001 [2]南华大学2013级卓越医师班,湖南衡阳421001 |
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| 基金项目： | 国家自然科学基金（81172890） |
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| 摘 要： | 目前获准上市的流脑疫苗主要有A群、A+C群脑膜炎球菌疫苗及A,C,W-135及Y群的四价脑膜炎球菌疫苗,B群脑膜炎球菌疫苗尚未研制成功。近年来,研究人员以疫苗外膜蛋白为基础,应用反向疫苗学技术对B群脑膜炎球菌疫苗进行了大量研究,现重点对B群脑膜炎球菌多组分疫苗的研究进展予以综述。
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| 关 键 词： | 脑膜炎奈瑟菌 B血清群 多组分 疫苗 |
Advances in development of multi-component vaccine for serogroup B neisseria meningitidis |
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| Institution: | LI Kai-ming, PENG Jie, ZI-IONG Mei-zhen, HU Si-hai (Institute of Pathogenic Biology, University of South China, Hengyang 421001 ,Hunan Province, China) |
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| Abstract: | The Neisseria meningitis （Nm） vaccines have been currently approved on the market including the group A , group A ＋ C vaccine and group A, C, W-135 and Y of tetravalent combination vaccine, up to now the development for serogroup B Nm vaccine has not successed. In recent years, researchers are concentrated in a vaccine based on the outer membrane proteins, the reverse vaccine technology is introduced in the research of serogroup B Nm vaccines. This paper fo- cuses on the development of multi-component vaccines for serogroup B Nm. |
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| Keywords: | Neisseria meningitidis （Nm） Serogroup B Multi-component Vaccine |
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