| 治疗性克隆研究的进展，机遇和挑战 |
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| 引用本文： | 任立晨,丁明孝.治疗性克隆研究的进展，机遇和挑战[J].生物化学与生物物理进展,2005,32(7):587-594. |
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| 作者姓名： | 任立晨 丁明孝 |
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| 作者单位： | 1. 上海交通大学生命科学学院,上海,200240
2. 北京大学生命科学学院,北京,100871 |
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| 摘 要： | 治疗性克隆为很多疾病的治疗提供了新的策略 . 以韩国科学家最近在这一领域的突破性进展为基点，回顾近年来这一领域的主要进展，着重对“核移植重编程”以及“人胚胎干细胞的建系，扩增和分化”这两个治疗性克隆策略中的关键问题进行评述，并对治疗性克隆的发展前景和目前所遇到的挑战进行了展望 .
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| 关 键 词： | 治疗性克隆，核移植，重编程，胚胎干细胞，细胞分化 |
Therapeutic Cloning: The Progresses, Opportunities and Challenges |
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| REN Li-Chen and DING Ming-Xiao.Therapeutic Cloning: The Progresses, Opportunities and Challenges[J].Progress In Biochemistry and Biophysics,2005,32(7):587-594. |
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| Authors: | REN Li-Chen and DING Ming-Xiao |
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| Institution: | College of Life Science, Shanghai Jiao Tong University, Shanghai 200240, China;College of Life Science, Peking University, Beijing 100871, China |
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| Abstract: | Therapeutic cloning has been suggested as a new strategy to treat a number of diseases. Based on the recent breakthrough made by Korean scientists, here the progresses in the field of therapeutic cloning were reviewed and two important issues in this field: the reprogramming after nuclear transfer and the establishment, self-renewal and differentiation of human embryonic stem cells were discussed. The great significance and existing challenges of therapeutic cloning strategy were also prospected. |
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| Keywords: | therapeutic cloning nuclear transfer reprogramming embryonic stem cell differentiation |
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