A small molecule inhibitor of alpha4 integrin-dependent cell migration |
| |
| Authors: | Lee Jongkook Hong Jiyong Nam Tae-Gyu Peters Eric C Orth Anthony P Geierstanger Bernhard H Goldfinger Lawrence E Ginsberg Mark H Cho Charles Y Schultz Peter G |
| |
| Affiliation: | Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA. |
| |
| Abstract: | ![]()
A small molecule inhibitor of alpha4 integrin-dependent cell migration was identified through a cell-based screen of small molecule libraries. Biochemical and cellular experiments suggest that this molecule functions by interacting with gamma-parvin. This molecule should serve as a useful tool to study alpha4 integrin signaling and may lead to new therapeutics for the treatment of autoimmune diseases. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ |
