Annotation of hypothetical proteins orthologous in Pongo abelii and Sus scrofa |
| |
Authors: | Singh Jitendra Ranjana Narula Shefali Agnihotri Maneet Singh |
| |
Institution: | 1Department of Bioinformatics, ADI Biosolution, Mohali, Punjab, India 160059;2Department of Bioinformatics, Hans Raj Mahila Mahavidyalaya, Jalandhar, Punjab, India |
| |
Abstract: | A hypothetical protein is predicted to be expressed from an open reading frame without known experimental evidence of translation. They constitute a substantial
fraction of proteomes. Domain extraction from these hypothetical sequences helps to search for protein coding genes for protein structural and functional
annotation. We describe the analysis of prediction data in a sequence dataset of hypothetical protein orthologs of Pongo abelii (orangutan) and Sus scrofa (pig). It
should be noted that these orangutan-pig orthologs are also non-homologous to human proteins. These predicted data find application in the genome wide
annotation of proteins in poorly understood genomes.AbbreviationsPDB - Protein Data Bank,
DEG - Database of Essential Genes,
CDD - Conserved Domain Database,
IUCN - International Union for Conservation of Nature. |
| |
Keywords: | Pongo abelii Sus scrofa hypothetical proteins functional annotation structure prediction subcellular localization |
|
|