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Biosynthesis of the RNA polymerase inhibitor streptolydigin in Streptomyces lydicus: tailoring modification of 3-methyl-aspartate |
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| Authors: | Horna Dina H Gómez Cristina Olano Carlos Palomino-Schätzlein Martina Pineda-Lucena Antonio Carbajo Rodrigo J Braña Alfredo F Méndez Carmen Salas José A |
| Affiliation: | 1Departamento de Biología Funcional e Instituto Universitario de Oncología del Principado de Asturias (IUOPA), Universidad de Oviedo, 33006 Oviedo, Spain;2Laboratorio de Bioquímica Estructural, Departamento de Biología Química, Centro de Investigación Príncipe Felipe, 46012 Valencia, Spain |
| Abstract: | The asparaginyl-tRNA synthetase-like SlgZ and methyltransferase SlgM enzymes are involved in the biosynthesis of the tetramic acid streptolydigin in Streptomyces lydicus. Inactivation of slgZ led to a novel streptolydigin derivative. Overexpression of slgZ, slgM, or both in S. lydicus led to a considerable increase in streptolydigin production. |
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