A new polymorphic marker (D10S97) tightly linked to the multiple endocrine neoplasia type 2A (MEN2A) locus |
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| Authors: | Jay B Lichter Jingshi Wu Angela R Brooks-Wilson Micheal Difillipantonio Stephanie Brewster David C Ward Paul J Goodfellow Kenneth K Kidd |
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| Institution: | (1) Department of Genetics, Yale University, 06510 New Haven, CT, USA;(2) Department of Pediatrics, UCSF, 94143 San Francisco, CA, USA;(3) Department of Medical Genetics, University of British Columbia, V6T1Z3 Vancouver, BC, Canada;(4) Department of Genetics, Yale University, School of Medicine, I-311 SHM, 333 Cedar Street, 06510 New Haven, CT, USA |
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| Abstract: | Familial multiple endocrine neoplasia type 2A (MEN 2A) is a cancer syndrome that is inherited as an autosomal dominant with high penetrance. Its clinical features are medullary carcinoma of the thyroid, pheochromocytomas, and hyperparathyroidism. A new polymorphic locus D10S97 (probe: KW6 SacI) detects a codominant EcoRI polymorphism that is tightly linked to the MEN2A locus. The peak lod score for linkage between D10S97 with MEN2A is 13.03 at  =0.00. The polymorphic locus D10S97 maps, by linkage analysis, into the previously defined interval between FNRB and RBP3 to which MEN2A has been assigned. We present physical mapping data showing that the probe pKW6 originates from 10p13 and that the polymorphic locus D10S97 in 10q11.2 is detected by cross-hybridization. |
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