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Fed-batch fermentation of Lactobacillus lactis for hyper-production of l-lactic acid |
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| Authors: | Dong-Mei Bai Qiang Wei Zhi-Hui Yan Xue-Ming Zhao Xin-Gang Li Shi-Min Xu |
| Affiliation: | (1) Department of Biochemical Engineering, School of Chemical Engineering & Technology, P.R. China;(2) National Engineering Research Center for Distillation Technology, Tianjin University, Tianjin, 300072, P.R. China;(3) Department of Biochemical Engineering, School of Chemical Engineering & Technology, Tianjin University, Tianjin, 300072, P.R. China |
| Abstract: | A fed-batch fermentation of Lactobacillus lactis to produce l-lactic acid was developed in which the residual glucose concentration in the culture was used to control a continuous feeding strategy. Up to 210 g l-lactic acid l–1 (97% yield) was obtained. The maximal dry cell was 2.7 g l–1 and the average l-lactic acid productivity was 2.2 g l–1 h–1. |
| Keywords: | fed-batch fermentation glucose feeding Lactobacillus lactis l-lactic acid |
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