Overexpression of CXCR1/CXCR2 on mesenchymal stromal cells may be an effective treatment for acute myocardial infarction |
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| Authors: | Jianzhong Xu Qizhi Chen Chunzhi Shi Zhaofang Yin |
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| Institution: | 1. Institute for Molecular Cardiovascular Research, RWTH Aachen University, Germany;2. Department of Cardiology, RWTH Aachen University, Germany;3. Institute for Biochemistry and Molecular Cell Biology, RWTH Aachen University, Germany;4. Department of Cardiothoracic and Vascular Surgery, Johann Wolfgang Goethe University, Frankfurt/Main, Germany;5. Department of Experimental Molecular Imaging, RWTH Aachen University, Germany;6. Victor Babes National Institute of Pathology, Bucharest, Romania;7. Department of Oral and Maxillofacial Surgery, RWTH Aachen University, Aachen, Germany;8. Department of Cellular and Molecular Medicine, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania;9. Institute for Cardiovascular Prevention, Ludwig MaximiliansUniversity (LMU) Munich, Munich, Germany;1. Department of Emergency Medicine, Beijing Key Laboratory of Cardiopulmonary Cerebral Resuscitation, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China;2. Department of Cardiology, Institute of Cardiovascular Diseases, First Affiliated Hospital of Dalian Medical University, Dalian 116011, China |
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| Abstract: | Bone marrow (BM)-derived mesenchymal stromal cells (MSC) participate in myocardial repair following myocardial infarction (MI). However, their reparative capability is limited, partly because of poor homing abilities. MI is associated with an inflammatory reaction. Interleukin-8 (IL-8) appears to have a fundamental role in regulating neutrophil localization in ischemic tissues through binding CXCR1/CXCR2 receptors, which show major expression on neutrophils. We hypothesize that the application of IL-8 will enhance the recruitment of overexpressing CXCR1/CXCR2 MSC to sites of degenerated tissue of myocardium, decreasing the ischemic region and improving cardiac function. |
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