The genetics of the sixth and seventh components of complement in the dog: Polymorphism,linkage, locus duplication,and silent alleles |
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| Authors: | P R Eldridge M J Hobart P J Lachmann |
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| Institution: | (1) MRC Mechanisms in Tumour Immunity Unit, MRC Centre, Hills Road, CB2 2QH Cambridge, U.K.;(2) Present address: St. Thomas's Hospital, Lambeth Palace Road, SE1 London, U.K. |
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| Abstract: | The complement components C6 and C7 exhibit genetic polymorphism in the domestic dog. In the case of C6, there is a single
locus with a null allele and two structural alleles; in the case of C7, there are two linked loci, each with three structural
alleles. There is a null allele or locus deletion at one of these loci. In all cases, inheritance is autosomal and codominant.
The C7 loci are closely linked to each other and to C6. This complex is not close to the dog major histocompatibility complex
(MHC) locus. |
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| Keywords: | dog complement C6 C7 polymorphism linkage |
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