MC4R Variant Is Associated With BMI but Not Response to Resistance Training in Young Females |
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| Authors: | Funda E Orkunoglu‐Suer Brennan T Harmon Heather Gordish‐Dressman Priscilla M Clarkson Paul D Thompson Theodore J Angelopoulos Paul M Gordon Monica J Hubal Niall M Moyna Linda S Pescatello Paul S Visich Robert F Zoeller Eric P Hoffman Joseph M Devaney |
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| Institution: | 1. Research Center for Genetic Medicine, Children's National Medical Center, Washington, DC, USA;2. Department of Kinesiology, University of Massachusetts, Amherst, Massachusetts, USA;3. Division of Cardiology, Henry Low Heart Center, Hartford Hospital, Hartford, Connecticut, USA;4. Center for Lifestyle Medicine, Department of Health Professions, University of Central Florida, Orlando, Florida, USA;5. Laboratory for Physical Activity and Exercise Intervention Research, University of Michigan, Ann Arbor, Michigan, USA;6. School of Health and Human Performance, Dublin City University, Dublin, Ireland;7. Department of Kinesiology, Human Performance Laboratory, University of Connecticut, Storrs, Connecticut, USA;8. Human Performance Laboratory, Central Michigan University, Mount Pleasant, Michigan, USA;9. Department of Exercise Science and Health Promotion, Florida Atlantic University, Davie, Florida, USA |
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| Abstract: | Recently, a genome‐wide association study (GWAS) that identified eight single‐nucleotide polymorphisms (SNPs) associated with BMI highlighted a possible neuronal influence on the development of obesity. We hypothesized these SNPs would govern the response of BMI and subcutaneous fat to resistance training in young individuals (age = 24 years). We genotyped the eight GWAS‐identified SNPs in the article by Willer et al. in a cohort (n = 796) that undertook a 12‐week resistance‐training program. Females with a copy of the rare allele (C) for rs17782313 (MC4R) had significantly higher BMIs (CC/CT: n = 174; 24.70 ± 0.33 kg/m2, TT: n = 278; 23.41 ± 0.26 kg/m2, P = 0.002), and the SNP explained 1.9% of overall variation in BMI. Males with a copy of the rare allele (T) for rs6548238 (TMEM18) had lower amounts of subcutaneous fat pretraining (CT/TT: n = 65; 156,534 ± 7,415 mm3, CC: n = 136; 177,825 ± 5,139 mm3, P = 0.019) and males with a copy of the rare allele (A) for rs9939609 (FTO) lost a significant amount of subcutaneous fat with exercise (AT/AA: n = 83; ?798.35 ± 2,624.30 mm3, TT: n = 47; 9,435.23 ± 3,494.44 mm3, P = 0.021). Females with a copy of the G allele for a missense variant in the SH2B1 (rs7498665) was associated with less change of subcutaneous fat volume with exercise (AG/GG: n = 191; 9,813 ± 2,250 mm3 vs. AA: n = 126; 770 ± 2,772 mm3; P = 0.011). These data support the original finding that there is an association between measures of obesity and a variant near the MC4R gene and extends these results to a younger population and implicates FTO, TMEM18, and SH2B1 polymorphisms in subcutaneous fat regulation. |
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