Interferon and sodium butyrate inhibit the stimulation of poly(ADP-ribose) synthetase in mouse cells stimulated to divide |
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| Authors: | Tauseef R. Butt Thazepadath Sreevalsan |
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| Affiliation: | 1. Laboratory of Cellular and Developmental Biology, NIADDK, NIH, Bethesda, MD 20205 U.S.A.;2. Department of Microbiology, Georgetown University, School of Medicine and Dentistry, Washington, DC 20007, USA |
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| Abstract: | The activity of poly(ADP-ribose) synthetase, a chromatin-bound enzyme, increases when quiescent 3T3 cells are stimulated to proliferate. The elevation of enzymatic activity requires de novo RNA and protein synthesis. Interferon (IFN) or sodium butyrate, when added to quiescent cells at the time of stimulation, suppressed the rise of enzymatic activity as well as initiation of DNA synthesis in cells. However, other DNA synthesis inhibitors like methotrexate, FudR and hydroxyurea had little effect on the elevation of poly(ADP-ribose) synthetase in quiescent cells. |
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