Beta-C-glycosiduronic acids and beta-C-glycosyl compounds: new PTP1B inhibitors |
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| Authors: | Lin Li Shen Qiang Chen Guo-Rong Xie Juan |
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| Institution: | PPSM, ENS Cachan, CNRS, UniverSud, 61 av President Wilson, F-94230 Cachan, France. |
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| Abstract: | Beta-C-glycosiduronic acid quinones and beta-C-glycosyl compounds have been synthesized as sugar-based PTP1B inhibitors. Benzoyl protected quinone derivatives (14 and 35) as well as aryl beta-C-glycosyl compounds (18, 22, 23 and 34) showed IC(50) values of 0.77-5.27 microM against PTP1B, with compounds 18 and 23 bearing an acidic function being the most potent. |
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