Interaction and cleavage of DNA with metal complexes of macrocyclic compound consisting of two 1, 10-phenanthroline. |
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| Authors: | M Hirai K Shinozuka H Sawai S Ogawa |
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| Institution: | Department of Chemistry, Faculty of Engineering, Gunma University, Japan. |
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| Abstract: | We have synthesized two metal complexes of the macrocyclic compound (III, IV), with which either Cu2+ or Ru2+ is coordinated, consisting of two 1,10-phenanthroline molecules bridged by sulfur. Interaction of the metal complexes with DNA was examined by spectroscopic method and their binding constants were determined. The DNA cleaving activities of these complexes were also investigated. |
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