IUGR胎鼠HRV谱分析实验研究

为了探讨将胎儿自主神经发育及其功能状况作为判断胎儿宫内发育迟缓(IUGR)的可行性，采用酒精灌胃加限食法建立IUGR动物模型，利用自回归(AR)模型法对IUGR胎鼠心率变异性(HRV)进行功率谱分析。结果表明，无论是低频功率、高频功率还是总功率，实验组均明显高于对照组，但标化后的高频功率实验组则明显低于对照组，标化后的低频功率实验组仍明显高于对照组。提示，利用FHRV谱分析评价胎儿自主神经发育及其功能状况，进而对IUGR进行产前诊断的方法是可行的。

The Experimental Study on Power Spectrum Analysis of HRV in IUGR Rats

The feasibility of diagnosing intrauterine growth retardation (IUGR) was investigated by evaluating the development and function of fetal autonomic nervous system (ANS).The animal model of IUGR was established by dietary restriction and drinking,the power spectrum of fetal rats' heart rate variability (HRV) was analyzed by autoregression (AR). The results showed that the total frequency (TF),low frequency (LF) and high frequency (HF) of power in the experimental group were all significantly higher than those in the control group,but the standardized HF of power in the experimental group became lower than those in the control group, the standardized LF of power in the experimental group remained significantly higher than those in the control group. It proved that the development and function of fetal ANS can be evaluated by power spectrum analysis,so power spectrum analysis can be used to diagnose IUGR.