|
|||||
|
|
Identification of novel single nucleotide polymorphisms (SNPs) of the lipoprotein lipase (LPL) gene associated with fatty acid composition in Korean cattle |
|
| Authors: | Dongyep Oh Boomi La Yoonseok Lee Younhwa Byun Jeayoung Lee Geunhye Yeo Jungsou Yeo |
| Institution: | 1. School of Biotechnology, Yeungnam University, Gyeongsan, Gyeongbuk, 712-749, South Korea 2. Institute of Charmpoom Hanwoo, Gyeongsan, Gyeongbuk, 712-210, South Korea 3. Department of Statistics, Yeungnam University, Gyeongsan-si, Gyeongbuk, 712-749, South Korea 4. Green Cross Research Center, 303 Bojeong-dong, Giheung-gu, Yongin, 446-770, South Korea |
| Abstract: | The lipoprotein lipase (LPL) gene can be considered a functional candidate gene that regulates fatty acid composition. In this study, genetic associations between fatty acid composition and exonic single nucleotide polymorphisms (SNPs) in the LPL gene were examined using 612 Korean cattle. We investigated the relationship between unsaturated fatty acids and five novel SNPs (c.322G>A, c.329A>T, c.527T>G, c.988C>T and c.1591G>A), and confirmed that three polymorphic SNPs (c.322G>A, c.329A>T and c.1591G>A) were associated with fatty acid composition. Korean cattle with an AA genotype of c.322G>A, c.329A>T, and GA genotype of c.1591G>A had higher levels of monounsaturated fatty acids and carcass traits (P < 0.05). Our findings confirmed that three novel SNPs we identified in the LPL gene can affect fatty acid composition and carcass traits. Therefore, selection for AA and GA genotypes should be recommended to genetically improve beef quality and flavor. |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ | |