| 拷贝数变异与疾病的关系及其在动物抗病育种中的应用前景 |
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| 引用本文： | 何阳花,俞英,张沅.拷贝数变异与疾病的关系及其在动物抗病育种中的应用前景[J].遗传,2008,30(11):1385-1391. |
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| 作者姓名： | 何阳花 俞英 张沅 |
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| 作者单位： | 中国农业大学动物科技学院, 北京 100193 |
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| 基金项目： | 我国奶牛群体遗传改良关键技术与优良育种材料引进项目 |
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| 摘 要： | 摘要: 拷贝数变异(Copy number variations, CNVs)主要指大于1 kb以上的DNA片段的缺失、插入、重复等。CNVs广泛存在于人类和其他哺乳动物的基因组中。文章主要介绍了CNVs对人类疾病的影响及其检测技术, 并对CNVs在动物抗病育种中的应用前景进行了展望。由于拷贝数变异对抗病性和易感性的影响至关重要, 因此采用生物技术手段有望将其运用于家畜标记辅助选择、QTL精细定位以及动物优良抗病品种培育当中。
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| 关 键 词： | 动物抗病育种 HapMap 单核苷酸多态性 拷贝数变异 |
| 收稿时间： | 2008-03-23 |
| 修稿时间： | 2008-06-09 |
Relationships between copy number variations and human disease and its perspective in animal disease-resistant breeding |
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| HE Yang-Hua,YU Ying,ZHANG Yuan.Relationships between copy number variations and human disease and its perspective in animal disease-resistant breeding[J].Hereditas,2008,30(11):1385-1391. |
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| Authors: | HE Yang-Hua YU Ying ZHANG Yuan |
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| Institution: | College of Animal Science and Technology, China Agricultural University, Beijing 100193, China |
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| Abstract: | Abstract: Copy number variations (CNVs) refer to the deletion, insertion, and duplication of genes over 1 kb in length. CNVs were widely found in human and other mammalian genomes. Here, we mainly reviewed the impacts of CNVs on the human diseases, and introduced the general detecting methods for CNVs. We also discussed the potential relationship be-tween CNVs and disease-resistant breeding of animals. Because of the significant effects of CNVs on the resistance and susceptibility of disease, CNVs can be used in the marker-assisted selection, QTL fine mapping, and disease-resistant breeding of livestocks by means of biotechnologies. |
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| Keywords: | HapMap |
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