Inhibition of protein kinase C activity by the Leishmania donovani lipophosphoglycan |
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| Authors: | T B McNeely S J Turco |
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| Affiliation: | Department of Biochemistry, University of Kentucky Medical Center, Lexington 40536. |
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| Abstract: | Purified lipophosphoglycan from Leishmania donovani was found to inhibit the activity of protein kinase C isolated from rat brain. Protein kinase C inhibition by lipophosphoglycan was continuous for 30 minutes. The glycoconjugate was a competitive inhibitor with respect to diolein, a noncompetitive inhibitor with respect to phosphatidylserine, and had no significant effect on protein kinase M and protein kinase A. A possible physiological role of lipophosphoglycan as a negative effector of protein kinase C is suggested. |
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