益生菌抑制幽门螺杆菌的作用机制及研究进展

幽门螺杆菌在胃部疾病的发病过程中起着重要作用，是导致胃炎、胃溃疡，甚至胃癌的关键因素之一。随着胃部疾病患者幽门螺杆菌阳性检出率的不断升高，人们对于胃病和幽门螺杆菌的相关性研究也有了一定进展。如今，对于幽门螺杆菌阳性患者根除治疗的必要性，以及抗生素治疗耐药性等问题已引起广泛关注。在这种情况下，益生菌作为相对安全的天然微生物，在抑制幽门螺杆菌并促进胃部健康的益生功能方面具有重要的研究潜力。本综述对幽门螺杆菌的致病机理、不同基因分型的致病程度等方面进行了总结，并对益生菌抑制幽门螺杆菌的机制进行了探讨。建议在治疗幽门螺杆菌感染时，应与常规的治疗手段结合应用，不仅会增加幽门螺杆菌的根除率，还能减少治疗相关的副作用。

Research progress in the mechanism of probiotics inhibiting Helicobacter pylori

Helicobacter pylori (Hp) plays a role in the pathogenesis of gastric diseases and is one of the key factors leading to gastritis, gastric ulcer, and even gastric cancer. With the continuous increase in the positive detection rate of Hp in patients with gastric diseases, scientists have achieved certain progress in the research on the association between gastric diseases and Hp. The eradication therapy for Hp-positive patients and the antibiotic resistance of Hp have attracted increasing attention. Probiotics, as relatively safe natural microorganisms, have great research potential and significance for their functions of inhibiting Hp and improving gastric health. This review summarizes the pathogenic mechanism of Hp and the pathogenicity of different genotypes, and then elaborates the mechanism of probiotics inhibiting Hp. It is recommended that the treatment of Hp infection should combine probiotics with conventional therapies, which will not only increase the eradication rate of Hp but also reduce the side effects associated with treatment.