The binding site for oxaloacetate on succinate dehydrogenase |
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| Authors: | A D Vinogradov D Winter T E King |
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| Affiliation: | Department of Chemistry State University of New York at Albany Albany, New York 12222 USA |
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| Abstract: | Oxaloacetate, a competitive inhibitor of succinate dehydrogenase, bound with a sulfhydryl group of the enzyme to abolish the enzymic activity. Subsequently a thiosemiacetal was apparently formed to render the inhibition practically irreversible. The dehydrogenase, after taking up 25 silver equivalents per flavin, bound little oxaloacetate. |
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