Synthesis, in vitro, and in vivo antibacterial activity of nocathiacin I thiol-Michael adducts |
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| Authors: | Naidu B Narasimhulu Sorenson Margaret E Bronson Joanne J Pucci Michael J Clark Junius M Ueda Yasutsugu |
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| Institution: | The Bristol-Myers Squibb Pharmaceutical Research Institute, 5 Research Parkway, Wallingford, CT 06492, USA. b.narasimhulunaidu@bms.com |
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| Abstract: | The synthesis and antibacterial activity of a series of nocathiacin I derivatives (4-20) containing polar water solubilizing groups is described. Thiol-Michael adducts containing acidic polar groups have reduced antibacterial activity whereas those with basic polar groups have retained very good antibacterial activity. |
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