Antioxidant activity of different molecular weight sulfated polysaccharides from <Emphasis Type="Italic">Ulva pertusa</Emphasis> Kjellm (Chlorophyta) |
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Authors: | Huimin?Qi Tingting?Zhao Email author" target="_blank">Quanbin?ZhangEmail author Zhien?Li Zengqin?Zhao Ronge?Xing |
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Institution: | (1) Institute of Oceanology, Chinese Academy of Sciences, Qingdao, 266071, P.R.China;(2) Graduate School of the Chinese Academy of Sciences, Beijing, 100039, P.R. China |
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Abstract: | Polysaccharides extracted from Ulva pertusa Kjellm (Chlorophyta) are a group of sulfated heteropolysaccharides, the ulvans. In this study, different molecular weight
ulvans were prepared by H2O2 degradation and their antioxidant activities investigated including superoxide and hydroxyl radical scavenging activity,
reducing power and metal chelating ability. The molecular weights of natural and degraded ulvans were 151.7, 64.5, 58.0, and
28.2 kDa, respectively, as determined by high performance gel permeation chromatography. Among the four samples, U3 (the lowest molecular weight sample) showed significant inhibitory effects on superoxide and hydroxyl radicals with IC50 values of 22.1 μ g mL−1 and 2.8 mg mL−1; its reducing power and metal chelating ability were also the strongest among the four samples. All the other samples also
demonstrated strong activity against superoxide radicals. The results indicated that molecular weight had a significant effect
on the antioxidant activity of ulvan with low molecular weight ulvan having stronger antioxidant activity. |
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Keywords: | antioxidant activity metal chelating ability molecular weight free radical scavenging effect reducing power ulvan |
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